engineering

Industrial Fermentation & Bioprocess Engineering

The engineering of large-scale biological production — bioreactor geometry and mixing, oxygen mass transfer, fed-batch substrate feeding strategies, continuous chemostat culture, and scale-up from bench to production.

fermentationbioreactorbioprocessoxygen transferfed-batchchemostatscale-up

Industrial fermentation harnesses microbial metabolism to manufacture products ranging from antibiotics and enzymes to biofuels and recombinant proteins. Designing and operating bioreactors at industrial scale demands precise control of mixing, aeration, nutrient feeding, and environmental conditions to maximize productivity while keeping cells healthy.

These simulations let you design stirred-tank bioreactor geometries, calculate oxygen transfer rates through gas-liquid interfaces, optimize fed-batch feeding profiles, analyze continuous chemostat steady states, and predict scale-up behavior from laboratory to production vessels — all with real-time interactive controls and industrially validated engineering correlations.

5 interactive simulations

simulator

Stirred-Tank Bioreactor Design

Simulate stirred-tank bioreactor geometry — optimize vessel dimensions, impeller configuration, and power input for microbial and mammalian cell culture

simulator

Continuous Culture & Chemostat

Simulate continuous chemostat culture — explore steady-state biomass, substrate, and dilution rate effects including washout and oscillatory dynamics

simulator

Fed-Batch Fermentation Strategy

Simulate fed-batch fermentation — optimize substrate feeding profiles to maximize biomass and product while avoiding overflow metabolism and substrate inhibition

simulator

Oxygen Transfer & kLa

Simulate oxygen mass transfer in bioreactors — calculate kLa, dissolved oxygen profiles, and the oxygen transfer rate as functions of agitation and aeration

simulator

Bioreactor Scale-Up

Simulate bioreactor scale-up from bench to production — compare scale-up criteria including constant P/V, tip speed, kLa, and mixing time across scales